Pre-Clinical Services

Sleep-Wake | Cognitive-Behavioral Testing | NeuroChemistry | Immunohistochemistry

Pre-Clinical NeuroChemistry

In vivo microdialysis and HPLC-EC separation of monoamine neurotransmitters is performed in the awake behaving rodent to determine neurochemical markers/pattern of transmitter release following pharmacological or environmental manipulations. Animals are housed in sound attenuated chambers to increase compound effect detection. Compounds can be given by a number of routes including: IP, SC, Oral, ICV. Deliverables from these studies include:

Monoamine Level Quantification

Norepinephrine (NE)
Dopamine (DA)
Serotonin (5-HT)
Monoamine Metabolites (DOPAC, HVA, etc.)

Dialysis Regions

Nucleus Accumbens
Prefrontal Cortex
Hippocampus
Thalamus
Custom anatomical region placements available

For reference see: C.W. Berridge, D.M. Devilbiss et al. 2006